توضیحات
This thesis sheds light on the identification and functional role of microRNAs (miRNAs) in neuroblastoma chemoresistance. Neuroblastoma is an embryonal malignancy of childhood and the biology of neuroblastoma tumors is complex and dramatically heterogeneous (Brodeur, 2003). Most of the children diagnosed above one year of age, shows metastatic disease and poor prognosis (Brodeur, 2003). Chemotherapy is one of the principle mode of treatment for the metastatic disease. However, resistance to drug represents the major clinical obstacle for the effective treatment of cancer. MiRNAs are small, endogenous, non-coding RNAs that reduce the translation of target mRNAs (Croce and Calin, 2005). Recently, miRNAs have been shown to modulate drug resistance in multiple cancers. However, the role of miRNAs in neuroblastoma chemoresistance is limited and poorly understood. In this study, we set out to identify miRNAs (and their networks/pathways) along with their functional targets involved in mediating drug resistance in neuroblastoma.
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